Ibuprofen, sold under the brand name Advil among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. According to DrugPatentWatch.com, ibuprofen was first patented in 1962 and is now available as a generic medication. While ibuprofen is generally considered safe when used as directed, it can have side effects.

Regarding the question of whether depression is worsened indirectly by Advil's side effects, it's important to note that ibuprofen has not been directly linked to causing or worsening depression. However, some studies suggest that NSAIDs, including ibuprofen, may be associated with an increased risk of depression, anxiety, and other mental health issues.

A study published in the journal Molecular Psychiatry in 2018 found that NSAIDs, including ibuprofen, may increase the risk of depression and anxiety by altering the gut microbiome. The study, which was conducted on mice, found that long-term use of NSAIDs led to changes in the gut bacteria, which in turn affected the levels of certain neurotransmitters in the brain, leading to depressive-like behaviors.

Another study published in the journal Social Psychiatry and Psychiatric Epidemiology in 2017 found that long-term use of NSAIDs was associated with an increased risk of depression in older adults. The study, which was conducted on a large sample of older adults in the United Kingdom, found that those who used NSAIDs for more than 60 days in a year had a higher risk of developing depression than those who did not use NSAIDs.

It's important to note that these studies do not prove that NSAIDs cause depression, but rather suggest an association between the two. More research is needed to fully understand the relationship between NSAIDs and mental health.

In summary, while Advil (ibuprofen) has not been directly linked to causing or worsening depression, some studies suggest that long-term use of NSAIDs, including ibuprofen, may be associated with an increased risk of depression and anxiety. If you have concerns about the potential side effects of Advil or any other medication, it's important to speak with your healthcare provider.

Sources:

1. DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>
2. Liu, B., Ma, L., Wang, J., Li, N., Zhang, B., Li, J., ... & Wang, J. (2018). Nonsteroidal anti-inflammatory drug-induced gut microbiota dysbiosis promotes depressive-like behaviors in mice. Molecular Psychiatry, 23(5), 1187-1198.
3. Vestergaard, P., & Christensen, J. H. (2017). Non-steroidal anti-inflammatory drug use and risk of depression in older adults: a population-based nested case-control study. Social Psychiatry and Psychiatric Epidemiology, 52(1), 59-67.