Lipitor is a brand name for the drug atorvastatin, which is a medication used to lower cholesterol levels in the body [1]. According to the National Health Service (NHS), there are several medications that can interact with atorvastatin, including painkillers such as ibuprofen and aspirin [3]. The interaction can lead to an increased risk of side effects such as stomach bleeding and kidney problems. Therefore, it is important to inform your doctor or pharmacist if you are taking any painkillers or other medications before taking Lipitor [3].

A study published in the National Center for Biotechnology Information (NCBI) also suggests that the combination of atorvastatin and nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of muscle damage and kidney injury [2]. The study recommends that patients who are taking both medications should be monitored closely for signs of muscle pain, weakness, or dark urine, which may indicate muscle or kidney damage.

In conclusion, painkillers such as ibuprofen and aspirin can interact with Lipitor, increasing the risk of side effects. Patients should inform their doctor or pharmacist if they are taking any painkillers or other medications before taking Lipitor. If a patient is taking both Lipitor and painkillers, they should be monitored closely for signs of muscle pain, weakness, or dark urine, which may indicate muscle or kidney damage [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.nhs.uk/medicines/atorvastatin/taking-atorvastatin-with-other-medicines-and-herbal-supplements/