Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body [1]. The drug works by blocking the production of cholesterol in the liver, which can lead to a decrease in low-density lipoprotein (LDL) cholesterol, also known as "bad" cholesterol. It is important to note that Lipitor may interact with other substances, including alcohol, which can affect its effectiveness.

According to a study published in the National Center for Biotechnology Information, moderate alcohol consumption does not significantly affect the pharmacokinetics of atorvastatin [2]. However, heavy alcohol consumption can lead to liver damage, which can affect the liver's ability to metabolize Lipitor, potentially leading to an increase in side effects and a decrease in effectiveness [3].

Furthermore, the Mayo Clinic notes that grapefruit and grapefruit juice can interact with Lipitor, leading to an increase in the drug's concentration in the bloodstream and potentially causing side effects [3]. Therefore, it is important to avoid consuming grapefruit or grapefruit juice while taking Lipitor.

In conclusion, moderate alcohol consumption does not appear to significantly affect the effectiveness of Lipitor. However, heavy alcohol consumption and the consumption of grapefruit or grapefruit juice can potentially lead to interactions and affect the drug's effectiveness. It is important to consult with a healthcare provider before consuming alcohol or other substances while taking Lipitor [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767327/
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013