When considering the combination of Lipitor (atorvastatin) and fish oil, it is essential to consult with a healthcare provider or pharmacist to ensure the safety and effectiveness of this combination. Here are some precautions to consider based on the available information:

1. Drug Interactions: Lipitor and fish oil may interact with each other, potentially affecting the blood levels of atorvastatin or the effectiveness of fish oil supplements. [1]

2. Liver Function: Both Lipitor and fish oil may affect liver function. Patients with liver problems or those taking medications that affect liver function should be cautious when combining these two. [1][2]

3. Muscle Pain: Statins like Lipitor can cause muscle pain or weakness, and fish oil may increase the risk of muscle-related side effects. [1][3]

4. Bleeding Risk: Fish oil may increase the risk of bleeding, especially when taken in high doses or with other medications that increase the risk of bleeding. Lipitor may also increase the risk of bleeding in some cases. [1][4]

5. Monitoring: Patients taking both Lipitor and fish oil should be monitored for potential side effects and changes in liver function, muscle pain, and bleeding risk. [1]

It is essential to consult a healthcare provider or pharmacist for personalized advice on combining Lipitor and fish oil, as individual factors may influence the safety and effectiveness of this combination.

Sources:

1. "Atorvastatin." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/meds/a601265.html.
2. "Fish Oil." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/natural/993.html.
3. "Statins." Mayo Clinic, Mayo Foundation for Medical Education and Research, 21 Jan. 2022, mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045773.
4. "Fish Oil." DrugPatentWatch, drugpatentwatch.com/drug/fish_oil.html.