Lipitor (atorvastatin) is a medication that is used to lower cholesterol levels in the blood. It is generally taken once a day, with or without food. However, there is some evidence to suggest that taking Lipitor with a fatty meal may affect its effectiveness.

According to a study published in the Journal of Clinical Pharmacology [3], taking Lipitor with a high-fat meal can significantly reduce its absorption into the bloodstream. The study found that taking Lipitor with a meal containing 50% fat reduced the maximum concentration of the drug in the blood by 48%, compared to taking it on an empty stomach.

Another study published in the Journal of Cardiovascular Pharmacology [2] found that taking Lipitor with food did not affect its effectiveness in lowering cholesterol levels. However, the study did not specifically look at the effect of a fatty meal on Lipitor absorption.

Despite these conflicting findings, it is generally recommended that Lipitor be taken on an empty stomach, or with a low-fat meal, in order to ensure maximum absorption and effectiveness [1]. Patients should always consult with their healthcare provider about the best way to take their medications.

In conclusion, while there is some evidence to suggest that taking Lipitor with a fatty meal may reduce its absorption and effectiveness, more research is needed to fully understand the extent of this effect. Patients should follow the recommended dosing instructions and consult with their healthcare provider about any concerns they may have.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/8568017/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/