When combining Advil (ibuprofen) and alcohol, there are potential risks and interactions to be aware of. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever.

Potential risks of mixing Advil with alcohol include:

1. Gastrointestinal issues: Both Advil and alcohol can irritate the lining of the stomach and intestines, increasing the risk of stomach ulcers, bleeding, and other gastrointestinal problems [1].

2. Kidney damage: Prolonged use of NSAIDs like Advil, especially in high doses, can lead to kidney damage or even kidney failure. Alcohol can also negatively affect kidney function, and when combined with Advil, the risk of kidney damage may be increased [1][2].

3. Liver issues: Although ibuprofen is not primarily metabolized by the liver, long-term use or high doses of NSAIDs can still cause liver damage. Alcohol is metabolized by the liver and is well-known for its potential to cause liver damage or disease. Combining the two may exacerbate liver issues [1][2].

4. Increased risk of bleeding: Both Advil and alcohol can thin the blood and increase the risk of bleeding. When taken together, this risk may be heightened [1].

5. Impaired judgment and coordination: Alcohol consumption can impair judgment, coordination, and reaction time. Taking Advil with alcohol may not necessarily increase these impairments, but it is essential to be aware that alcohol alone can significantly affect cognitive and motor functions [1].

It is crucial to consult a healthcare professional or pharmacist for personalized advice regarding the use of Advil and alcohol, as individual risks and interactions may vary.

Sources:
[1] https://www.drugs.com/drug-interactions/ibuprofen-with-alcohol-13-1-553-555.html
[2] https://www.drugpatentwatch.com/ibuprofen