Lipitor, also known as atorvastatin, is a medication that is used to lower cholesterol levels in the blood. It is classified as a statin drug and works by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver [1]. While Lipitor is generally well-tolerated, some patients may experience side effects such as muscle pain, liver damage, and an increase in blood pressure [2].
According to a study published in the Journal of Clinical Hypertension, statins like Lipitor can cause an increase in blood pressure in some patients. The study found that patients who took statins had a small but significant increase in both systolic and diastolic blood pressure compared to those who did not take statins [3].
It is not entirely clear why statins can cause an increase in blood pressure. One theory is that statins can reduce the production of nitric oxide, a molecule that helps to relax blood vessels and lower blood pressure. Another theory is that statins can interfere with the production of a hormone called aldosterone, which regulates blood pressure [3].
It is important to note that not all patients who take Lipitor will experience an increase in blood pressure. However, if you are taking Lipitor and notice a sudden increase in blood pressure, it is important to talk to your doctor. They may recommend adjusting your dosage or switching to a different medication [2].
In summary, while Lipitor is generally a safe and effective medication for lowering cholesterol levels, it can cause an increase in blood pressure in some patients. The exact mechanism behind this side effect is not fully understood, but it may be related to the drug's effects on nitric oxide and aldosterone production. If you are taking Lipitor and experience a sudden increase in blood pressure, it is important to talk to your doctor.
Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.pennmedicine.org/news/news-blog/2019/april/a-cardiologists-take-on-the-keto-diet
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016087/