Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the body, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation. Both drugs can interact with other medications and affect their efficacy and safety.

According to the sources provided, there is no direct information on how the dosage of Lipitor affects its interaction with ibuprofen. However, it is known that ibuprofen can interact with Lipitor and increase the risk of side effects, such as muscle pain and liver damage [2]. Therefore, it is recommended to use these medications together with caution and under the supervision of a healthcare provider.

It is also important to note that Lipitor can interact with other medications, including ritonavir-boosted nirmatrelvir (Paxlovid), which is used to treat COVID-19 [3]. This interaction can increase the risk of side effects, such as muscle pain and kidney damage, and may require a dosage adjustment or monitoring of the patient's condition.

In summary, the sources provided do not offer specific information on how the dosage of Lipitor affects its interaction with ibuprofen. However, it is known that ibuprofen can interact with Lipitor and increase the risk of side effects. Patients should use these medications together with caution and under the supervision of a healthcare provider. It is also important to be aware of other medications that can interact with Lipitor, such as ritonavir-boosted nirmatrelvir.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.everydayhealth.com/drugs/lipitor
[3] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/