Tylenol, also known as acetaminophen, is a common over-the-counter medication used to relieve pain and reduce fever. Proton pump inhibitors (PPIs) are a type of medication used to reduce the amount of acid produced in the stomach.

According to the Drug Patent Watch [1], there are no known interactions between Tylenol and PPIs. However, it is always recommended to consult with a healthcare provider before taking any new medication or combining medications.

A study published in the Journal of Clinical Pharmacology [2] found that there was no significant interaction between acetaminophen and omeprazole, a commonly used PPI. The study concluded that it is safe to take acetaminophen with omeprazole.

The Federal Aviation Administration (FAA) provides a list of over-the-counter medications that are approved for pilots to take [3]. Both Tylenol and PPIs are on the list, indicating that they are considered safe for pilots to take.

In summary, based on the provided sources, there are no known interactions between Tylenol and PPIs, and it is generally considered safe to take them together. However, it is always recommended to consult with a healthcare provider before taking any new medication or combining medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/TYLENOL
[2] https://pubmed.ncbi.nlm.nih.gov/10405233/
[3] https://www.faa.gov/licenses_certificates/medical_certification/media/OTCMedicationsforPilots.pdf