Lipitor is a medication used to lower cholesterol levels in the blood. It is important to note that the effectiveness of Lipitor may be affected by certain foods and medications. However, the sources provided do not specifically mention whether Lipitor can be taken with high-fat foods like guacamole.

According to the first source [1], Lipitor's absorption may be reduced when taken with certain foods, such as grapefruit juice, which can increase the concentration of the medication in the blood. However, there is no mention of guacamole or any other high-fat foods.

The second source [2] provides information on the best and worst fats to eat on a ketogenic diet, but it does not address the interaction between Lipitor and high-fat foods.

The third source [3] discusses the potential interactions between medications and food. It notes that certain foods can affect the absorption and effectiveness of medications, but again, there is no specific mention of guacamole or high-fat foods in general.

In conclusion, while the sources provided do not offer a definitive answer, it is generally recommended to take Lipitor with a low-fat meal or at least one hour before or two hours after a high-fat meal. Patients should consult with their healthcare provider or pharmacist for specific instructions on how to take Lipitor and whether it can be taken with guacamole or other high-fat foods.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.everydayhealth.com/ketogenic-diet/diet/best-worst-fats-eat-on-keto-diet/
[3] https://www.statnews.com/2016/11/03/medications-food-drug-interactions/