Lipitor (atorvastatin) is a medication that is commonly used to lower cholesterol levels in the body. When taking Lipitor, it is important to be aware of any potential interactions with other medications, including painkillers.

According to the National Health Service (NHS) [2], it is generally safe to take Lipitor with most painkillers, including paracetamol (acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin. However, it is important to note that taking high doses of NSAIDs for a long period of time may increase the risk of muscle damage when taken with Lipitor.

The website Drug Patent Watch [1] also notes that there are no known drug interactions between Lipitor and common painkillers such as acetaminophen, aspirin, and ibuprofen.

However, it is important to always consult with a healthcare professional before taking any new medications, including painkillers, while on Lipitor. This is because there may be individual factors that could increase the risk of interactions or side effects.

In summary, it appears that most painkillers, including acetaminophen and NSAIDs such as ibuprofen and aspirin, are generally safe to take with Lipitor. However, it is always important to consult with a healthcare professional before taking any new medications while on Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.nhs.uk/medicines/atorvastatin/taking-atorvastatin-with-other-medicines-and-herbal-supplements/
[3] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details