Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body [1]. There is no direct evidence to suggest that Lipitor can worsen opioid side effects. However, opioids can cause excessive sweating as a side effect [3]. Lipitor has been known to cause muscle pain and weakness, which can be exacerbated when taken with certain medications, including opioids [2]. It is important to note that any medication combination should be discussed with a healthcare provider to ensure safe and effective treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.goodrx.com/drugs/side-effects/medications-cause-excessive-sweating-side-effect