Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. According to Drug Patent Watch [1], Lipitor works by inhibiting an enzyme in the liver that is responsible for producing cholesterol. This medication is commonly prescribed alongside lifestyle changes such as a healthy diet and exercise.

There are certain food-drug interactions that can affect the absorption of Lipitor. According to US Pharmacist [2], fatty meals can reduce the absorption of atorvastatin by up to 30%. Therefore, it is recommended to take Lipitor with a low-fat meal or on an empty stomach. Additionally, grapefruit and grapefruit juice should be avoided as they can increase the levels of Lipitor in the blood, leading to an increased risk of side effects.

A study published in PubMed [3] supports the findings of US Pharmacist. The study concluded that the bioavailability of atorvastatin was reduced by 36% when taken with a high-fat meal. The study also found that taking atorvastatin with grapefruit juice increased the area under the curve (AUC) by 16%, indicating an increased level of the medication in the blood.

In summary, Lipitor can be affected by certain food-drug interactions. Fatty meals can reduce the absorption of atorvastatin, and grapefruit and grapefruit juice should be avoided. It is recommended to take Lipitor with a low-fat meal or on an empty stomach. Patients should consult with their healthcare provider or pharmacist for specific instructions on how to take Lipitor and avoid any potential food-drug interactions.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.uspharmacist.com/article/fooddrug-interactions
[3] https://pubmed.ncbi.nlm.nih.gov/20449528/