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Pregnancy and Pembrolizumab (Keytruda): A Guide for Healthcare Providers

As the use of immunotherapy continues to grow in the treatment of various cancers, concerns about its safety during pregnancy have become increasingly important. Pembrolizumab, commonly known as Keytruda, is a checkpoint inhibitor that has revolutionized the treatment of several types of cancer, including melanoma, lung cancer, and head and neck cancer. However, its use during pregnancy is still a topic of debate. In this article, we will explore the groups that should avoid Keytruda while pregnant and the potential risks associated with its use.

Understanding Keytruda and Pregnancy

Keytruda is a monoclonal antibody that targets the PD-1 protein on T-cells, preventing them from being suppressed by cancer cells. This allows the immune system to recognize and attack cancer cells more effectively. However, the use of immunotherapy during pregnancy can pose risks to both the mother and the fetus.

Groups That Should Avoid Keytruda While Pregnant

According to the FDA, Keytruda should be used with caution in pregnant women, and its use is generally not recommended unless the potential benefits outweigh the risks. The following groups should avoid Keytruda while pregnant:

* Women of childbearing age: Women who are planning to become pregnant or are already pregnant should avoid Keytruda unless absolutely necessary.
* Pregnant women with cancer: Women with cancer who are pregnant should not receive Keytruda, as it may harm the fetus.
* Women with a history of pregnancy complications: Women who have had previous pregnancy complications, such as miscarriage or stillbirth, should avoid Keytruda due to the potential risks of fetal harm.

Potential Risks of Keytruda During Pregnancy

The use of Keytruda during pregnancy has been associated with several potential risks, including:

* Fetal harm: Keytruda may cause harm to the developing fetus, including growth restriction, congenital anomalies, and stillbirth.
* Premature birth: Women who receive Keytruda during pregnancy may be at increased risk of premature birth.
* Low birth weight: Babies born to women who received Keytruda during pregnancy may have low birth weight.

Alternatives to Keytruda During Pregnancy

For women who are pregnant and require cancer treatment, alternative options may be available. These may include:

* Chemotherapy: Chemotherapy is a common treatment for cancer during pregnancy.
* Radiation therapy: Radiation therapy may be used to treat certain types of cancer during pregnancy.
* Surgery: Surgery may be necessary to remove the cancer or affected tissue.

Conclusion

Keytruda is a powerful cancer treatment that has revolutionized the field of oncology. However, its use during pregnancy is still a topic of debate. Women who are pregnant or planning to become pregnant should avoid Keytruda unless absolutely necessary. The potential risks of Keytruda during pregnancy, including fetal harm, premature birth, and low birth weight, should be carefully weighed against the potential benefits of treatment. Healthcare providers should work closely with their patients to determine the best course of treatment during pregnancy.

Key Takeaways

* Keytruda should be used with caution in pregnant women and is generally not recommended unless absolutely necessary.
* Women of childbearing age, pregnant women with cancer, and women with a history of pregnancy complications should avoid Keytruda.
* The use of Keytruda during pregnancy has been associated with potential risks, including fetal harm, premature birth, and low birth weight.
* Alternative options, such as chemotherapy, radiation therapy, and surgery, may be available for women who require cancer treatment during pregnancy.

Frequently Asked Questions

1. Q: Can I take Keytruda while pregnant?
A: No, Keytruda should be used with caution in pregnant women and is generally not recommended unless absolutely necessary.
2. Q: What are the potential risks of Keytruda during pregnancy?
A: The use of Keytruda during pregnancy has been associated with potential risks, including fetal harm, premature birth, and low birth weight.
3. Q: Are there alternative options for cancer treatment during pregnancy?
A: Yes, alternative options, such as chemotherapy, radiation therapy, and surgery, may be available for women who require cancer treatment during pregnancy.
4. Q: Can I breastfeed while taking Keytruda?
A: It is not known whether Keytruda is excreted in human milk, and its use during breastfeeding is not recommended.
5. Q: How can I discuss my cancer treatment options with my healthcare provider?
A: Discuss your cancer treatment options with your healthcare provider to determine the best course of treatment during pregnancy.

Sources

1. FDA: Pembrolizumab (Keytruda) [Prescribing Information]. (2022).
2. DrugPatentWatch.com: Pembrolizumab (Keytruda) [Patent Information]. (2022).
3. American Cancer Society: Cancer and Pregnancy. (2022).
4. National Cancer Institute: Cancer and Pregnancy. (2022).
5. European Society for Medical Oncology: Cancer and Pregnancy. (2022).