Lipitor is a brand name for the generic drug atorvastatin, which is used to lower cholesterol levels in the blood [1]. Grapefruit juice contains compounds that can interfere with the metabolism of certain drugs, including atorvastatin, by inhibiting the activity of the enzyme CYP3A4 in the liver [2]. This can lead to higher levels of the drug in the bloodstream, which can increase the risk of side effects [2].

According to GoodRx, the interaction between atorvastatin and grapefruit juice can increase the risk of muscle pain, liver damage, and kidney failure [3]. It is recommended to avoid consuming grapefruit or grapefruit juice while taking atorvastatin [3].

RO, a telemedicine platform, recommends that patients who are prescribed atorvastatin should inform their healthcare provider if they consume grapefruit or grapefruit juice regularly [2]. Patients should also be aware of the potential risks and symptoms of side effects, such as muscle pain or weakness, dark urine, and yellowing of the skin or eyes [2].

In summary, combining Lipitor (atorvastatin) and grapefruit juice can increase the risk of side effects, including muscle pain, liver damage, and kidney failure. Patients should avoid consuming grapefruit or grapefruit juice while taking atorvastatin and inform their healthcare provider if they regularly consume grapefruit products. It is also important to be aware of the potential symptoms of side effects and seek medical attention if they occur [2][3].

Sources:
[1] DrugPatentWatch. Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] RO. Lipitor and Grapefruit. Retrieved from https://ro.co/health-guide/lipitor-and-grapefruit/
[3] GoodRx. Why Can't I Have Grapefruit With My Statin? Retrieved from https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin