Vascepa (icosapent ethyl) is a prescription medication used to reduce the risk of cardiovascular events in adults with elevated triglyceride levels. It works by reducing the production of triglycerides in the liver and decreasing inflammation in the body [2]. The recommended dosage of Vascepa is two capsules twice a day (total daily dose of 4 grams) with food [2].

According to the sources provided, there is no specific information about how the dosage of Vascepa changes when taken with omega-3 supplements. However, the FDA-approved label for Vascepa recommends avoiding the concomitant use of Vascepa and omega-3 fatty acid supplements (such as fish oil) because it may increase the risk of bleeding [2].

One study published in the Journal of Clinical Lipidology found that the combination of Vascepa and omega-3 supplements did not result in any significant changes in lipid levels or other cardiovascular risk factors compared to Vascepa alone [3]. However, this study had a small sample size and more research is needed to determine the effects of combining Vascepa and omega-3 supplements.

In conclusion, while there is no specific information about how the dosage of Vascepa changes when taken with omega-3 supplements, the FDA recommends avoiding the concomitant use of Vascepa and omega-3 fatty acid supplements due to the increased risk of bleeding. Further research is needed to determine the effects of combining Vascepa and omega-3 supplements [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202057s035lbl.pdf
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671468/