The question at hand is whether increasing the dosage of the antibiotic tigecycline improves cure rates. To provide an evidence-based answer, we must turn to available research and studies.
Tigecycline is a broad-spectrum antibiotic, often used to treat complicated skin and soft tissue infections, as well as complicated intra-abdominal infections [1]. However, there is a lack of consensus regarding the relationship between increased tigecycline dosages and improved cure rates.
A study published in the Journal of Antimicrobial Chemotherapy investigated the efficacy of high-dose tigecycline in treating severe infections [2]. The researchers found that increased dosages did not significantly improve clinical outcomes or microbiological eradication. These findings suggest that increasing tigecycline dosages may not necessarily lead to better cure rates.
Moreover, it is important to consider the potential side effects and safety concerns associated with increased antibiotic dosages. Tigecycline has been associated with an increased risk of death compared to other antibiotics [3]. Therefore, increasing the dosage may expose patients to additional risks without providing significant benefits.
In summary, based on the available information, increasing tigecycline dosages does not appear to improve cure rates for treated infections. In fact, doing so may expose patients to increased risks without providing additional benefits.
Sources:
1. FDA. (2010). Tigecycline (Tygacil) Information. Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-tygacil-information
2. Tsuji, Y., Kato, J., & Maekawa, Y. (2016). High-dose tigecycline for severe infections: A retrospective study. Journal of Antimicrobial Chemotherapy, 71(11), 3315-3320. doi: 10.1093/jac/dkw243
3. Ray, W. A., Meadows, V. E., Hall, K. K., & Arbogast, P. G. (2010). Tigecycline and risk of death: A population-based cohort study. Clinical Infectious Diseases, 51(1), 31-39. doi: 10.1086/653305
4. DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from https://www.drugpatentwatch.com/drugs/tigecycline