Lipitor, a medication used to treat high cholesterol, may require dose adjustments based on several factors. These factors include the patient's kidney function, liver function, and other health conditions [1].

Generally, dose adjustments for Lipitor are not based on the time of initiation but rather on the patient's response to the medication and changes in their health status. For instance, if a patient develops kidney problems, their doctor may need to adjust the dose of Lipitor to prevent accumulation of the drug in the body, which could lead to toxicity [1].

Moreover, Lipitor is primarily metabolized by the liver, and any liver dysfunction can affect the drug's metabolism. Therefore, in such cases, the doctor may decide to reduce the dose or monitor the patient closely for any adverse effects [1].

It is important to note that Lipitor has a patent that expired in 2011 [2]. This means that there are generic versions of the drug available, which may have different dosing instructions. Therefore, it is crucial to follow the specific dosing instructions provided by the healthcare provider and the drug manufacturer [1].

In conclusion, while Lipitor dose adjustments are not typically based on the time of initiation, they may be necessary based on changes in a patient's health status. It is essential to consult with a healthcare provider for personalized dosing instructions.

Sources:
[1] "Lipitor-atorvastatin Calcium Tablet, Film Coated." DailyMed, National Library of Medicine, 20 Jan. 2022, https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6d8b5e1e-d7b4-4e1e-a7d1-f4a1f2a5a89c&type=display.
[2] "Lipitor (Atorvastatin Calcium) Drug Patent Expiration." DrugPatentWatch, 2022, https://www.drugpatentwatch.com/drugs/lipitor.html.