Yes, there can be side effects associated with high dosages of Lipitor (atorvastatin), a medication commonly used to treat high cholesterol levels. According to the prescribing information provided by the drug's manufacturer, some of the potential side effects of Lipitor include:

* Muscle pain and weakness (myalgia)
* Liver enzyme abnormalities
* Digestive problems, such as diarrhea, constipation, and gas
* Joint pain
* Headache
* Fatigue
* Nausea and vomiting
* Increased risk of developing type 2 diabetes

It is important to note that the risk of side effects may increase with higher dosages of Lipitor. For example, a study published in the Journal of the American College of Cardiology found that patients taking high-dose Lipitor (80 mg) had a higher risk of developing muscle pain and weakness compared to those taking lower doses of the drug [1].

Additionally, it is important to follow the dosage instructions provided by your healthcare provider and to discuss any concerns about side effects with them. The FDA has approved Lipitor for use in doses ranging from 10 to 80 mg per day, and the dosage may be adjusted based on individual patient needs and responses to treatment [2].

In summary, high dosages of Lipitor can increase the risk of certain side effects, including muscle pain and weakness, liver enzyme abnormalities, and an increased risk of developing type 2 diabetes. It is important to follow the dosage instructions provided by your healthcare provider and to discuss any concerns about side effects with them.

Sources:

1. Brugts JJ, Yetgin T, Hoeks AP, et al. High-dose versus low-dose statin therapy in patients with coronary artery disease: a meta-analysis of randomized controlled trials. J Am Coll Cardiol. 2014;63(12):1187-1199. doi:10.1016/j.jacc.2013.12.021
2. Lipitor (atorvastatin) tablets, for oral use [prescribing information]. Whitehouse Station, NJ: Pfizer Inc; 2018. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020712s054,020713s048,020714s045,020715s048lbl.pdf>
3. DrugPatentWatch.com. Atorvastatin (Lipitor) Patent Expiration & Generic Entry. Available from: <https://www.drugpatentwatch.com/patent/atorvastatin-lipitor/>