There is no evidence to suggest that Vascepa, a prescription medication used to lower triglyceride levels, can lower alcohol tolerance. The sources provided do not mention any such side effect or interaction between Vascepa and alcohol. However, it is important to note that excessive alcohol consumption can increase triglyceride levels, which is one of the conditions that Vascepa is used to treat. Therefore, individuals who consume alcohol excessively may benefit from reducing their alcohol intake to help manage their triglyceride levels. As with any medication, it is recommended to consult with a healthcare provider before combining Vascepa with alcohol or making any significant changes to one's alcohol consumption.

Sources:
[1] Drug Patent Watch. Vascepa. https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] UpToDate. Hypertriglyceridemia in adults: Management. https://www.uptodate.com/contents/hypertriglyceridemia-in-adults-management
[3] Healthline. Vascepa. https://www.healthline.com/health/drugs/vascepa