Lipitor, also known as atorvastatin, is a widely used medication to lower cholesterol levels in the body. The question is whether splitting Lipitor tablets affects its effectiveness.

According to the first source, Drug Patent Watch [1], Lipitor is available in tablet form in various strengths ranging from 10mg to 80mg. The tablets are not scored, meaning they are not designed to be easily divided into smaller doses. The second source, a study published in the Journal of Clinical Pharmacology [2], investigated the effect of splitting Lipitor tablets on its bioavailability. The study concluded that splitting Lipitor tablets did not significantly affect its bioavailability, which means that the effectiveness of the medication remains the same even after splitting the tablets.

However, the third source, a document from the Royal Pharmaceutical Society [3], advises against splitting tablets that are not scored, as it can lead to uneven dosing and affect the medication's effectiveness. It is recommended to use a pill splitter to ensure that the tablet is divided evenly.

In conclusion, while splitting Lipitor tablets may not significantly affect its effectiveness, it is still advisable to use a pill splitter to ensure an even dose. Patients should consult their healthcare provider or pharmacist before splitting Lipitor tablets or any other medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/11847935/
[3] https://www.rpharms.com/Portals/0/RPS%20document%20library/Open%20access/Support/toolkit/pharmaceuticalissuesdosageforms-%282%29.pdf