According to the information provided, Lipitor, a medication also known as atorvastatin, can be taken with or without food [2]. However, it is recommended to take it in the evening [2]. It is also advised to take Lipitor at the same time every day to help maintain consistent levels of the drug in your body [2].

While it is generally safe to take Lipitor with food, it's important to note that grapefruit and grapefruit juice can increase the amount of Lipitor in your blood and lead to unwanted side effects [3]. Therefore, it is usually recommended to avoid consuming grapefruit products while taking Lipitor [3].

In addition, certain conditions may require a modification in dosage or a different approach to taking Lipitor. For instance, if you have kidney or liver disease, your doctor may adjust your dosage [1]. Similarly, if you are taking certain medications, such as blood thinners or some antibiotics and antifungals, your doctor may recommend taking Lipitor at a different time [1].

In conclusion, while Lipitor can be taken with or without food, it is advisable to take it in the evening and avoid consuming grapefruit products. However, individual circumstances may necessitate adjustments to this general guidance. Always consult with a healthcare provider for personalized advice.

Sources:
[1] https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/precautions/drg-20067003?p=1
[2] https://www.nhs.uk/medicines/atorvastatin/how-and-when-to-take-atorvastatin/
[3] https://www.drugpatentwatch.com/p/tradename/LIPITOR