Vascepa (icosapent ethyl) is a prescription medication used to treat high levels of triglycerides in the blood. According to the sources provided, Vascepa's absorption mechanism involves the conversion of icosapent ethyl into its active metabolite, EPA (eicosapentaenoic acid), in the small intestine [1][2][3].

Icosapent ethyl is a highly purified form of EPA that is chemically derived from fish oil. It is a prodrug, which means that it is inactive until it is metabolized in the body. Once icosapent ethyl is ingested, it is broken down by pancreatic enzymes in the small intestine, releasing EPA. The EPA is then absorbed into the bloodstream and transported to the liver, where it is further metabolized and incorporated into various tissues throughout the body [2].

The absorption of Vascepa is not affected by food intake, so it can be taken with or without food [2]. It is important to note that Vascepa should be taken as directed by a healthcare provider, as the dosage and duration of treatment may vary depending on individual patient needs.

In summary, Vascepa's absorption mechanism involves the conversion of icosapent ethyl into its active metabolite, EPA, in the small intestine. The EPA is then absorbed into the bloodstream and transported to the liver for further metabolism and incorporation into various tissues throughout the body.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.rxlist.com/vascepa-drug.htm
[3] https://reference.medscape.com/drug/vascepa-icosapent-999764