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Are there any alternative cholesterol medications that don t affect calcium absorption?



Based on the information available, there are indeed alternative cholesterol medications that do not affect calcium absorption.

Statins are a common class of cholesterol-lowering drugs that work by blocking a substance your body needs to make cholesterol [1]. However, some statins can affect the body's ability to absorb calcium. For instance, simvastatin (Zocor) has been reported to interact with calcium supplements, potentially reducing the absorption of the former [2].

An alternative class of cholesterol-lowering drugs are the bile acid sequestrants, such as cholestyramine (Prevalite), colesevelam (Welchol), and colestipol (Colestid) [1]. These medications work by binding to bile acids in the intestine and preventing their reabsorption, which leads to an increased demand for cholesterol to produce more bile acids, thereby lowering LDL cholesterol levels [1]. Importantly, these drugs do not interact with calcium absorption [3].

Another class of cholesterol-lowering drugs are the PCSK9 inhibitors, such as alirocumab (Praluent) and evolocumab (Repatha). These drugs work by binding to PCSK9, a protein that reduces the liver's ability to remove LDL cholesterol from the blood, thereby increasing the liver's uptake and breakdown of LDL cholesterol [1]. These drugs do not interact with calcium absorption [3].

In conclusion, while some statins can interact with calcium absorption, alternatives such as bile acid sequestrants and PCSK9 inhibitors do not interact with calcium absorption.

Sources:
[1] Mayo Clinic. Cholesterol medication: Which type is right for you? https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/cholesterol-medication/art-20045935
[2] Drugs.com. Simvastatin. https://www.drugs.com/drug-interactions/simvastatin,calcium-carbonate-2031-128-13.html
[3] DrugPatentWatch.com. Calcium and Cholesterol Medications. https://www.drugpatentwatch.com/insights/calcium-and-cholesterol-medications/



Follow-up:   Do any cholesterol drugs alter calcium levels? Can certain cholesterol medicines impact calcium? Are there cholesterol drugs not affecting calcium uptake?





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