Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. The drug works by inhibiting the production of an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver [1].

There is limited information available on how Lipitor affects body composition. However, a study published in the Journal of Clinical Endocrinology and Metabolism found that atorvastatin use was associated with a small but significant increase in body weight and body mass index (BMI) [2].

The study followed 1,000 healthy individuals for a period of 6 months and found that those who took atorvastatin had an average weight gain of 1.6 kg and an average increase in BMI of 0.6 kg/m2. The authors of the study suggest that this weight gain may be due to an increase in appetite and a decrease in physical activity in response to the medication [2].

Another study published in the Journal of Cardiovascular Pharmacology found that atorvastatin use was associated with a decrease in visceral fat, which is the fat that surrounds the organs in the abdominal cavity and is associated with an increased risk of cardiovascular disease [3]. The study followed 72 individuals with metabolic syndrome for a period of 6 months and found that those who took atorvastatin had a significant decrease in visceral fat compared to those who did not take the medication.

In conclusion, while there is limited information available on how Lipitor affects body composition, some studies suggest that it may be associated with a small increase in body weight and BMI, possibly due to an increase in appetite and a decrease in physical activity. However, atorvastatin use may also be associated with a decrease in visceral fat, which is beneficial for reducing the risk of cardiovascular disease. It is important to note that individual responses to medication may vary and patients should always consult with their healthcare provider regarding any concerns about medication side effects [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/23959724/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949584/