Methotrexate is a medication used to treat several medical conditions, including cancer, psoriasis, and rheumatoid arthritis. Although it is generally well-tolerated, some patients may experience side effects, especially elderly patients.

According to the Drug Patent Watch [1], common side effects of methotrexate include nausea, vomiting, loss of appetite, and fatigue. These side effects are usually mild and can be managed with proper medical care. However, some elderly patients may experience more severe side effects, such as liver toxicity, bone marrow suppression, and lung problems.

A study published in PubMed [2] investigated the safety and efficacy of methotrexate in elderly patients with rheumatoid arthritis. The study found that methotrexate was effective in reducing the symptoms of rheumatoid arthritis in elderly patients, but some patients experienced side effects such as gastrointestinal problems, liver dysfunction, and infections. The study concluded that methotrexate can be safely used in elderly patients with rheumatoid arthritis, but careful monitoring is necessary to detect and manage potential side effects.

MedlinePlus [3] also lists several side effects of methotrexate, including stomach pain, diarrhea, hair loss, and skin rash. The website warns that methotrexate can cause serious side effects, such as liver damage, lung problems, and decreased blood cell counts. It advises patients to seek medical attention immediately if they experience symptoms such as fever, chills, cough, shortness of breath, or unusual bleeding or bruising.

In summary, methotrexate is generally well-tolerated, but elderly patients may be more susceptible to side effects. Common side effects include nausea, vomiting, loss of appetite, and fatigue, while more severe side effects can include liver toxicity, bone marrow suppression, and lung problems. Elderly patients with rheumatoid arthritis can safely use methotrexate, but careful monitoring is necessary to detect and manage potential side effects. Patients should be aware of the possible side effects of methotrexate and seek medical attention if they experience any unusual symptoms.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://pubmed.ncbi.nlm.nih.gov/8972245/
[3] https://medlineplus.gov/druginfo/meds/a682019.html