Lipitor is a medication used to lower cholesterol levels in the blood. According to the sources provided, food intake does not significantly affect the effectiveness of Lipitor. Lipitor is a statin drug that works by inhibiting an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver [2].

According to a study published in the US National Library of Medicine, there was no significant difference in the effectiveness of Lipitor between the fasting and non-fasting groups [2]. However, the study suggests that taking Lipitor with food may reduce the incidence of gastrointestinal side effects such as nausea and abdominal pain [2].

The Mayo Clinic also states that Lipitor can be taken with or without food, and it is not necessary to time the medication with meals [3]. However, the clinic recommends avoiding grapefruit and grapefruit juice while taking Lipitor, as they can increase the level of the drug in the blood and increase the risk of side effects [3].

In conclusion, food intake does not significantly affect the effectiveness of Lipitor. It is safe to take Lipitor with or without food, and taking it with food may reduce the incidence of gastrointestinal side effects. However, it is important to avoid grapefruit and grapefruit juice while taking Lipitor to reduce the risk of side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312230/
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013