Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while antihistamines are a class of drugs used to treat allergies and cold symptoms. When taken together, there is a potential for drug interactions and side effects.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and antihistamines. However, it is important to note that this does not mean that there are no potential side effects.

One study published in the Journal of Pharmacy Practice and Research [2] found that some antihistamines, such as diphenhydramine (Benadryl), can increase the risk of muscle damage when taken with statins, including Lipitor. This is because both drugs can cause muscle damage on their own, and when taken together, the risk is increased.

Another article from BuzzRX [3] also warns against combining Benadryl with statins, as it can increase the risk of muscle pain and weakness. The article also advises against combining other antihistamines, such as chlorpheniramine and hydroxyzine, with statins due to potential interactions.

In conclusion, while there are no known drug interactions between Lipitor and antihistamines, some antihistamines, such as diphenhydramine (Benadryl), can increase the risk of muscle damage when taken with statins like Lipitor. It is important to talk to a healthcare provider before combining any medications to avoid potential side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.buzzrx.com/blog/medications-that-should-never-be-combined-with-benadryl