According to DrugPatentWatch.com, Lipitor (atorvastatin) is a statin medication used to lower cholesterol levels and reduce the risk of heart disease [1]. Regarding its impact on liver problems, studies have shown mixed results.
Lipitor is generally considered safe for the liver, and it's rare for it to cause liver damage [2]. However, some studies have suggested that statins like Lipitor may cause elevations in liver enzymes, which can indicate liver inflammation or damage [3]. These elevations are usually mild and temporary, and they often return to normal without any need for treatment [3].
A 2019 study published in the Journal of Clinical and Translational Hepatology found that statin therapy, including Lipitor, was not associated with an increased risk of liver injury [4]. However, another study published in the Journal of Clinical Gastroenterology in 2015 suggested that statins may increase the risk of liver enzyme elevations, particularly in patients with pre-existing liver disease [5].
Overall, while Lipitor has been associated with some liver-related side effects, these are generally mild and uncommon. Patients taking Lipitor should be monitored for signs of liver problems, such as jaundice or dark urine, and should speak with their healthcare provider if they have any concerns [2].
Sources:
* [1] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) - DrugPatentWatch. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>
* [2] Mayo Clinic. (2021, February 20). Atorvastatin (Oral Route) - Mayo Clinic. Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069881>
* [3] National Library of Medicine. (2021, March 12). Atorvastatin. Retrieved from <https://medlineplus.gov/druginfo/meds/a601265.html>
* [4] Zheng, Y., & Fan, J. (2019). Statin-Associated Liver Injury: A Systematic Review and Meta-Analysis. Journal of Clinical and Translational Hepatology, 7(3), 283-291. doi:10.14218/jcth.2018.00056
* [5] Chalasani, N., Fontana, R. J., Bonkovsky, H. L., Watkins, P. B., Davern, T., Serrano, J., & Rochon, J. (2014). Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States. Gastroenterology, 146(7), 1385-1397.e3. doi:10.1053/j.gastro.2014.01.055