Vascepa (icosapent ethyl) is a prescription medication used to treat high levels of triglycerides in the blood. It is a type of omega-3 fatty acid that is purified and concentrated. Vascepa works by reducing the production of triglycerides in the liver and increasing the breakdown of triglycerides in the blood [2].

The absorption of Vascepa is improved due to its unique chemical structure. Vascepa is a highly purified form of eicosapentaenoic acid (EPA) ethyl ester, which is a type of omega-3 fatty acid. It is a single isomer of EPA, which means that it contains only one active form of the molecule. This unique structure allows for greater absorption and bioavailability of the drug compared to other omega-3 fatty acid supplements [3].

The absorption of Vascepa is also enhanced by the presence of food. According to the FDA-approved label, Vascepa should be taken with food to increase absorption [2]. The presence of food in the stomach stimulates the release of bile, which helps to emulsify the drug and improve its absorption [3].

In conclusion, Vascepa's unique chemical structure, as well as the presence of food, helps to improve its absorption. Vascepa is a highly purified form of EPA ethyl ester, which allows for greater bioavailability compared to other omega-3 fatty acid supplements. The presence of food in the stomach also helps to emulsify the drug and improve its absorption [2][3].

Sources:
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202057s035lbl.pdf
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379293/