See the DrugPatentWatch profile for vascepa

Yes, there can be potential side effects when combining Vascepa (a prescription drug used to lower triglyceride levels) and statins (a class of drugs often used to treat high cholesterol). According to the Vascepa label information from the U.S. Food and Drug Administration (FDA) [1], the most common adverse reactions include:

1. Inflammation of the nasal passages and throat (nasopharyngitis)
2. Increased blood levels of the liver enzyme alanine aminotransferase (ALT)
3. Increased blood levels of the muscle enzyme creatine phosphokinase (CPK)

When Vascepa is combined with statins, the risk of muscle-related side effects, such as muscle pain, weakness, or damage (myopathy), may increase [1]. This is because both Vascepa and statins can affect muscle function independently.

Additionally, the FDA label for Vascepa states that there have been rare reports of rhabdomyolysis, a serious condition in which muscle tissue breaks down rapidly, leading to kidney damage [1]. This risk may be higher when Vascepa is combined with statins.

It's important to note that individual responses to drug combinations can vary, and not everyone will experience side effects. Patients should consult their healthcare provider for personalized advice regarding the use of Vascepa and statins together.

Sources:
[1] U.S. Food and Drug Administration. (2021). Highlights of Prescribing Information: Vascepa (icosapent ethyl) Capsules. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/202677s013lbl.pdf
[2] DrugPatentWatch.com. (n.d.). Vascepa. Retrieved from https://www.drugpatentwatch.com/drugs/vascepa