Lipitor (atorvastatin) is a prescription medication used to lower cholesterol levels, while St. John's Wort is a herbal supplement that is commonly used to treat depression and anxiety. According to the sources provided, combining Lipitor and St. John's Wort can be risky.

St. John's Wort can speed up the breakdown of certain medications in the liver, including Lipitor. This can lead to decreased effectiveness of Lipitor and potentially increase the risk of side effects. Additionally, St. John's Wort can also interact with other medications, including antidepressants, birth control pills, and blood thinners.

The Mayo Clinic advises patients to avoid taking St. John's Wort while on Lipitor or other cholesterol-lowering medications, unless under the guidance of a healthcare professional. The NHS also recommends caution when taking St. John's Wort with Lipitor, as it may reduce the effectiveness of the medication.

It is important to always consult with a healthcare professional before combining any medications or supplements, including Lipitor and St. John's Wort. Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions and ensure the safest and most effective treatment plan.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/drugs-supplements-st-johns-wort/art-20362212
[3] https://www.nhs.uk/medicines/atorvastatin/taking-atorvastatin-with-other-medicines-and-herbal-supplements/