Lipitor is a medication used to lower cholesterol levels in the body [1]. Grapefruit and its juice contain compounds that can interfere with the metabolism of certain drugs, including Lipitor [2]. This can lead to increased levels of the drug in the bloodstream, which can cause serious side effects such as muscle pain, liver damage, and kidney failure [3].

Grapefruit contains compounds called furanocoumarins, which inhibit the activity of an enzyme called CYP3A4. This enzyme is responsible for breaking down Lipitor in the liver. When the activity of CYP3A4 is inhibited, the levels of Lipitor in the bloodstream can increase significantly, leading to potential side effects [2].

Therefore, it is recommended to avoid consuming grapefruit or its juice while taking Lipitor. Other citrus fruits, such as oranges and lemons, do not contain furanocoumarins and do not interfere with the metabolism of Lipitor [3].

In conclusion, grapefruit contains compounds that can interfere with the metabolism of Lipitor, leading to increased levels of the drug in the bloodstream and potential side effects. It is recommended to avoid consuming grapefruit or its juice while taking Lipitor [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045
[3] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins