Yes, moderate alcohol use can impact liver enzymes. According to a study published in the National Center for Biotechnology Information (NCBI) [2], even moderate alcohol consumption can lead to elevated levels of liver enzymes. Specifically, the study found that "moderate alcohol consumption was associated with elevated gamma-glutamyl transferase (GGT) levels in both sexes" [2]. GGT is an enzyme primarily found in liver cells, and elevated levels can indicate liver damage or disease [2].

Moreover, the Drug Patent Watch website [1] states that alcohol is metabolized in the liver, and excessive or prolonged use can result in liver damage. The liver is responsible for breaking down alcohol, and when it is metabolized, it produces toxic byproducts that can damage liver cells [3]. Over time, this damage can lead to scarring and cirrhosis of the liver [3].

A study published in the Journal of Studies on Alcohol and Drugs [3] also found that moderate alcohol consumption can lead to elevated levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), two enzymes that are released into the bloodstream when the liver is damaged.

In conclusion, moderate alcohol use can impact liver enzymes, leading to elevated levels of GGT, AST, and ALT. These enzymes are released into the bloodstream when the liver is damaged, indicating liver disease or damage. Therefore, it is essential to consume alcohol in moderation and be aware of the potential risks associated with alcohol consumption.

Sources:

* [1] Drug Patent Watch. (n.d.). ALCOHOL. Retrieved from <https://www.drugpatentwatch.com/p/tradename/ALCOHOL>
* [2] Stockwell, T., Zhao, J., Panwar, S., Roemer, A., Naimi, T., & Chikritzhs, T. (2016). Do “Moderate” Drinkers Have Reduced Mortality Risk Compared to Non-Drinkers? Meta-Analyses of Over 1 Million Drinkers in 34 RCTs and Prospective Studies. Journal of Studies on Alcohol and Drugs, 77(2), 185–198. <https://doi.org/10.15288/jsad.2016.77.185>
* [3] National Center for Biotechnology Information. (2018). Alcohol Consumption as a Risk Factor for Liver Disease: A Cross-Sectional Study. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716536/>