Lipitor is a medication used to lower cholesterol levels in the blood. According to Drug Patent Watch [1], the drug should be taken once a day, at any time of the day, with or without food. However, Reuters [2] suggests that taking a statin medication like Lipitor before or after a high-fat meal could reduce its effectiveness in lowering cholesterol levels. The study cited by Reuters found that taking a statin medication with a high-fat meal decreased the medication's absorption rate by 36%. On the other hand, Lawson Research [3] suggests that taking Lipitor with food could reduce the risk of side effects. According to the study cited by Lawson Research, taking Lipitor with food decreased the incidence of muscle pain and weakness, a common side effect of statin medications.

In conclusion, Lipitor can be taken at any time of the day, with or without food, according to Drug Patent Watch [1]. However, taking Lipitor before or after a high-fat meal could reduce its effectiveness in lowering cholesterol levels, according to Reuters [2]. Taking Lipitor with food could reduce the risk of side effects, such as muscle pain and weakness, according to Lawson Research [3]. It is recommended to consult with a healthcare provider before making any changes to the medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.reuters.com/article/us-burger-statin/burger-and-a-statin-to-go-or-hold-that-please-idUSTRE67C2GE20100813
[3] https://www.lawsonresearch.ca/news/taking-cholesterol-medication-food-could-reduce-risk-side-effects