Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. According to Drug Patent Watch [1], Lipitor is not known to interact with opioids. However, it is important to note that opioids themselves can cause respiratory depression, and when taken with other medications that have a similar effect, the risk of respiratory depression may increase.

A study published in the US National Library of Medicine [2] found that opioids and statins, like Lipitor, have different mechanisms of action and do not interact with each other. The study did note that opioids can cause constipation, and statins can cause gastrointestinal side effects such as diarrhea, nausea, and abdominal pain. Therefore, it is important to monitor any gastrointestinal symptoms when taking both medications.

In an article by Express Scripts [3], it is stated that Pfizer's COVID-19 pill, Paxlovid, may interact with certain medications, but Lipitor is not mentioned as one of them. However, the article does mention that individuals taking Paxlovid should consult with their healthcare provider before taking any new medications, including over-the-counter medications and supplements.

In conclusion, Lipitor does not appear to interact with opioids according to Drug Patent Watch [1] and a study published in the US National Library of Medicine [2]. However, it is important to monitor any gastrointestinal symptoms when taking both medications. Individuals taking Paxlovid should consult with their healthcare provider before taking any new medications, including Lipitor, according to an article by Express Scripts [3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351822/
[3] https://www.express-scripts.com/pharmacy/blog/pfizers-covid-19-pill-and-medication-interactions