Yes, Vascepa can be used for high cholesterol. Vascepa is a prescription medication that contains the active ingredient icosapent ethyl, which is a type of omega-3 fatty acid [1]. The medication is used to lower triglyceride levels in adults with severe (200 mg/dL or higher) hypertriglyceridemia [1]. However, it is also often used off-label to help manage high cholesterol levels [2].

Vascepa works by reducing the production of very low-density lipoprotein (VLDL) in the body, which in turn lowers triglyceride levels [1]. VLDL is a type of lipoprotein that carries fat molecules, such as triglycerides, around the body [3]. High levels of VLDL can lead to the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries [3].

Several studies have shown that Vascepa can help lower triglyceride levels and reduce the risk of cardiovascular events in people with high cholesterol [1][2]. For example, a large clinical trial known as the REDUCE-IT study found that Vascepa reduced the risk of major adverse cardiovascular events by 25% in patients with high triglycerides and established cardiovascular disease [2].

It is important to note that Vascepa is not a substitute for a healthy lifestyle, and it should be used in conjunction with a heart-healthy diet and regular exercise [1]. Patients should also inform their healthcare provider of any other medications they are taking, as Vascepa can interact with certain drugs [1].

In summary, Vascepa can be used for high cholesterol, as it has been shown to lower triglyceride levels and reduce the risk of cardiovascular events in people with high cholesterol. However, it should be used in conjunction with a heart-healthy lifestyle and under the guidance of a healthcare provider.

Sources:

1. Vascepa (icosapent ethyl) [prescribing information]. Amarin Pharma, Inc.; 2021. <https://www.vascepa.com/sites/default/files/Vascepa-PI-Dec2020.pdf>
2. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22. doi:10.1056/NEJMoa1812797
3. What are lipoproteins? National Heart, Lung, and Blood Institute. <https://www.nhlbi.nih.gov/health-topics/lipoproteins>