Vascepa is a prescription medication that contains the active ingredient icosapent ethyl, which is used to reduce the risk of heart attack, stroke, and other cardiovascular events in people with high triglyceride levels [1]. Antidepressants, on the other hand, are medications used to treat depression, anxiety, and other mood disorders [2].

According to the available sources, there are no known interactions between Vascepa and antidepressants. However, it is important to note that Vascepa can cause certain side effects such as joint pain, swelling, and stiffness, and these side effects may be more pronounced in people who are also taking antidepressants [3]. Therefore, it is important to discuss any potential side effects or concerns with a healthcare provider before taking Vascepa with antidepressants.

Furthermore, the sources suggest that Vascepa can be taken long-term, as it has been shown to be safe and effective for up to five years of continuous use in clinical trials [1]. However, the decision to continue taking Vascepa long-term should be made in consultation with a healthcare provider, who can assess the individual's overall health and determine the most appropriate course of treatment.

In conclusion, there are no known interactions between Vascepa and antidepressants, but it is important to discuss any potential side effects or concerns with a healthcare provider before taking Vascepa with antidepressants. Vascepa can be taken long-term, but the decision to continue treatment should be made in consultation with a healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628733/
[3] https://www.singlecare.com/blog/vascepa-side-effects/