According to the sources provided, there is no indication that taking Vascepa with antidepressants is unsafe. However, it is important to note that any medication combination should be discussed with a healthcare provider before taking them together.

Vascepa (icosapent ethyl) is a prescription medication used to lower triglyceride levels in adults with high levels of triglycerides. The drug works by reducing the production of triglycerides in the liver and increasing their clearance from the blood [1].

The sources provided do not mention any interactions between Vascepa and antidepressants. However, Drugs.com advises patients to inform their healthcare provider about all medications they are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. This is important because some medications may interact with each other, causing unwanted side effects or reducing the effectiveness of one or both medications [2].

SingleCare notes that some people may experience side effects while taking Vascepa, such as joint pain, swelling, and a rash. However, these side effects are not related to antidepressants [3].

In conclusion, there is no evidence to suggest that taking Vascepa with antidepressants is unsafe. However, patients should always consult with their healthcare provider before taking any new medication or combination of medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.drugs.com/tips/vascepa-patient-tips
[3] https://www.singlecare.com/blog/vascepa-side-effects/