Lipitor is a medication that is commonly used to lower cholesterol levels in patients with high cholesterol. It works by inhibiting an enzyme that is responsible for the production of cholesterol in the liver. However, it is unclear whether Lipitor can counteract the effects of a low-fat diet.

According to the drug label [2], Lipitor is intended to be used in conjunction with a low-fat diet. The label recommends that patients adhere to a standard cholesterol-lowering diet before starting Lipitor and continue the diet during treatment. The label also states that Lipitor is effective in reducing cholesterol levels in patients with or without hyperlipidemia, which is a condition characterized by high levels of lipids in the blood.

A study published in the Journal of the American Medical Association [3] found that a low-fat diet combined with Lipitor was more effective in reducing LDL cholesterol levels than either intervention alone. The study involved 120 overweight and obese individuals with high cholesterol levels. Participants were randomly assigned to one of four groups: a low-fat diet, Lipitor, a combination of Lipitor and a low-fat diet, or a control group. The results showed that the combination of Lipitor and a low-fat diet was the most effective intervention, resulting in a 50% reduction in LDL cholesterol levels.

Another study published in the American Journal of Cardiology [1] found that Lipitor was effective in reducing cholesterol levels in patients who adhered to a low-fat diet. The study involved 132 patients with hyperlipidemia who were randomly assigned to receive either Lipitor or a placebo. The results showed that Lipitor was more effective than the placebo in reducing LDL cholesterol levels in patients who adhered to a low-fat diet.

In conclusion, Lipitor is a medication that is commonly used to lower cholesterol levels in patients with high cholesterol. It is intended to be used in conjunction with a low-fat diet, and studies have shown that a low-fat diet combined with Lipitor is more effective in reducing LDL cholesterol levels than either intervention alone. Therefore, Lipitor can be used to counteract the effects of a high-fat diet, but it is most effective when used in combination with a low-fat diet.

Sources:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312230/
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020702s073lbl.pdf
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849981/