Lipitor is a brand name for the drug atorvastatin, which is a type of statin used to lower cholesterol levels in the blood [1]. According to RxList, there are no known food interactions with Lipitor, and it can be taken with or without food [3]. However, certain foods may interfere with the effectiveness of statins, and some foods may help to enhance their effects.

Prevention recommends eating foods that are low in saturated and trans fats, such as avocados, which are the main ingredient in guacamole. Avocados are also high in heart-healthy monounsaturated fats, fiber, and potassium, which can help to lower cholesterol levels and reduce the risk of heart disease [2].

Overall, there is no evidence to suggest that consuming guacamole while taking Lipitor is unsafe. In fact, eating avocados may help to enhance the cholesterol-lowering effects of the medication. However, it is always important to consult with a healthcare provider before making any changes to your diet or medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.prevention.com/food-nutrition/g20509737/what-to-eat-if-you-take-statins/
[3] https://www.rxlist.com/lipitor-drug.htm