Based on the available information, combining Advil (ibuprofen) with antidepressants could potentially lead to increased risks of certain side effects. However, the specific risks depend on the type of antidepressant being taken.

According to the National Institute on Alcohol Abuse and Alcoholism, ibuprofen can increase the risk of stomach bleeding when taken with antidepressants that belong to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) [${3}]. This interaction may also occur with other types of antidepressants, although it is less well-studied.

Additionally, a study published in the Journal of Clinical Psychopharmacology found that the use of ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) [${2}].

It is important to note that these potential risks do not necessarily mean that individuals should avoid taking Advil and antidepressants together. Instead, they should consult with their healthcare provider to determine the best course of treatment for their specific situation.

In summary, the potential risks of combining Advil and antidepressants include an increased risk of stomach bleeding and a potential reduction in the effectiveness of certain antidepressants. However, individuals should consult with their healthcare provider before making any decisions about their medication regimen.

Sources:

* [Advil Information](https://www.drugpatentwatch.com/p/tradename/ADVIL)
* [Alcohol and Medication Interactions](https://www.niaaa.nih.gov/health-professionals-communities/core-resource-on-alcohol/alcohol-medication-interactions-potentially-dangerous-mixes)
* [Ibuprofen and Antidepressant Interactions](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/)