See the DrugPatentWatch profile for aspirin

Aspirin has been associated with stomach irritation, which is a common side effect of this medication. According to the article from the National Center for Biotechnology Information (NCBI) [${3}], aspirin can cause irritation and erosion of the gastrointestinal mucosa, leading to symptoms such as stomach pain, heartburn, and nausea.

In comparison, newer drugs for pain relief, such as non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, may have a lower risk of stomach irritation compared to aspirin. According to the article from the University of Tennessee Medical Center [${2}], newer NSAIDs such as ibuprofen and naproxen may be less likely to cause stomach irritation than aspirin. However, it is important to note that all NSAIDs carry some risk of stomach irritation, and long-term use of these medications can increase the risk of serious side effects such as ulcers and bleeding.

Acetaminophen, another common pain reliever, is generally considered to have a lower risk of stomach irritation compared to aspirin and NSAIDs. According to the article from the NCBI [${3}], acetaminophen is less likely to cause gastrointestinal side effects than NSAIDs, making it a suitable alternative for individuals who are sensitive to stomach irritation.

In summary, aspirin has been associated with stomach irritation, while newer drugs for pain relief, such as NSAIDs and acetaminophen, may have a lower risk of stomach irritation. However, it is important to note that all medications carry some risk of side effects, and individuals should consult with a healthcare provider to determine the most appropriate treatment for their specific needs.

Sources:

* <https://www.drugpatentwatch.com/p/tradename/ASPIRIN>
* <https://www.utmedicalcenter.org/blog-post/know-difference-between-your-pain-relievers>
* <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478398/>