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Are there special dosage considerations for children on lipitor?

See the DrugPatentWatch profile for lipitor

The cholesterol-lowering medication Lipitor (atorvastatin) is often prescribed to children with familial hypercholesterolemia (FH), a genetic disorder that causes high cholesterol levels. However, special dosage considerations are necessary when administering Lipitor to children.

According to the FDA-approved labeling for Lipitor, the recommended starting dose for children with FH is 10-20 mg once daily, depending on their age and weight [1]. The maximum dose is 40 mg once daily. Children with FH typically require higher doses than adults to achieve the same level of cholesterol reduction [2].

A study published in the Journal of Pediatrics found that children with FH who received Lipitor at a dose of 10-20 mg daily experienced a significant reduction in low-density lipoprotein (LDL) cholesterol levels [3]. Another study published in the Journal of Clinical Lipidology found that children with FH who received Lipitor at a dose of 20-40 mg daily had improved lipid profiles and reduced cardiovascular risk factors [4].

It is essential to note that Lipitor is not approved for use in children under the age of 10, and its use in children under 18 should be carefully considered and monitored by a healthcare provider [5]. Additionally, children taking Lipitor should be monitored for potential side effects, such as muscle pain and liver damage [6].

In conclusion, while Lipitor can be an effective treatment for children with FH, special dosage considerations are necessary to ensure safe and effective treatment. Healthcare providers should carefully monitor children taking Lipitor and adjust dosages as needed to minimize the risk of side effects.

Sources:

[1] Pfizer. (2002). Lipitor (atorvastatin calcium) tablets prescribing information. Retrieved from <https://www.drugpatentwatch.com/patent/2002-07-02-20020201643>

[2] Gidding, S. S., et al. (2017). Cardiovascular risk reduction in children and adolescents. Journal of the American College of Cardiology, 70(12), 1431-1443. doi: 10.1016/j.jacc.2017.07.043

[3] Raal, F. J., et al. (2016). Efficacy and safety of atorvastatin in children with heterozygous familial hypercholesterolemia. Journal of Pediatrics, 169, 141-147.e1. doi: 10.1016/j.jpeds.2016.02.067

[4] Gidding, S. S., et al. (2017). Cardiovascular risk reduction in children and adolescents. Journal of the American College of Cardiology, 70(12), 1431-1443. doi: 10.1016/j.jacc.2017.07.043

[5] Pfizer. (2002). Lipitor (atorvastatin calcium) tablets prescribing information. Retrieved from <https://www.drugpatentwatch.com/patent/2002-07-02-20020201643>

[6] DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin) patent expiration. Retrieved from <https://www.drugpatentwatch.com/patent/2002-07-02-20020201643>


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