Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body. It works by blocking an enzyme that produces cholesterol in the liver [1].

There is limited information available on whether it is safe to take Lipitor with high-fat meals. One study published in the Journal of Clinical Pharmacology suggests that taking Lipitor with a high-fat meal does not significantly affect its effectiveness in reducing cholesterol levels [2]. However, the study also notes that taking Lipitor with food can increase the absorption of the drug, which could lead to an increased risk of side effects [2].

Another study published in the Journal of Pharmaceutical Sciences found that taking Lipitor with a high-fat meal could lead to a delay in the drug's absorption, which could decrease its effectiveness in reducing cholesterol levels [3].

Overall, there is no clear consensus on whether it is safe to take Lipitor with high-fat meals. It is recommended to take Lipitor as directed by a healthcare provider and to avoid consuming large amounts of grapefruit juice, as it can increase the levels of Lipitor in the body and lead to an increased risk of side effects [1].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/