Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, there are certain painkillers that can interact negatively with Lipitor.

The first source, Drug Patent Watch [1], does not provide information on painkillers that interact with Lipitor.

The second source, a study published in the National Center for Biotechnology Information [2], suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen can interact with Lipitor. These painkillers can increase the risk of muscle damage (myopathy) when taken with Lipitor. The study recommends that patients taking Lipitor should avoid high doses of NSAIDs or take them only for a short period of time.

The third source, the COVID-19 Treatment Guidelines [3], states that the antiviral medication ritonavir-boosted nirmatrelvir (Paxlovid) can interact with Lipitor. Paxlovid can increase the levels of Lipitor in the blood, which can increase the risk of side effects such as muscle pain and liver damage. The guidelines recommend that patients taking Lipitor should avoid taking Paxlovid or should be closely monitored for side effects if they need to take both medications.

In summary, according to the sources provided, NSAIDs such as ibuprofen and naproxen can interact negatively with Lipitor and increase the risk of muscle damage. Additionally, the antiviral medication Paxlovid can increase the levels of Lipitor in the blood and increase the risk of side effects. Patients taking Lipitor should avoid high doses of NSAIDs or Paxlovid, or should be closely monitored for side effects if they need to take both medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/