The sources provided do not offer information on the timeline for Lipitor's impact on flexibility. However, the sources provide information on Lipitor's effectiveness in reducing cholesterol levels and preventing cardiovascular diseases. According to the Drug Patent Watch [1], Lipitor (atorvastatin calcium) is a medication used to lower cholesterol levels and reduce the risk of heart disease. It is a statin medication that works by blocking the production of cholesterol in the liver. The medication is effective in reducing low-density lipoprotein (LDL) cholesterol levels, also known as "bad" cholesterol, which is a major risk factor for cardiovascular diseases.
The study published in the Journal of the American Heart Association [3] indicates that atorvastatin therapy (Lipitor) has been shown to improve endothelial function in patients with coronary artery disease. Endothelial function is an important factor in maintaining blood vessel flexibility and preventing the development of atherosclerosis. The study found that after 6 months of atorvastatin therapy, there was a significant improvement in endothelial function in patients with coronary artery disease.
Another study published in the National Library of Medicine [2] shows that Lipitor can also improve arterial stiffness, which is another factor in maintaining blood vessel flexibility. The study found that after 12 weeks of atorvastatin therapy, there was a significant improvement in arterial stiffness in patients with type 2 diabetes and dyslipidemia.
In conclusion, while the sources provided do not offer information on the timeline for Lipitor's impact on flexibility, they suggest that Lipitor can improve endothelial function and arterial stiffness, which are important factors in maintaining blood vessel flexibility and preventing the development of atherosclerosis. It is important to note that the effectiveness of Lipitor may vary depending on the individual and other factors such as diet and exercise. Therefore, it is recommended to consult with a healthcare provider before starting any medication.
Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686951/
[3] https://www.ahajournals.org/doi/10.1161/01.cir.0000126280.65777.a4.