See the DrugPatentWatch profile for lipitor

Based on the provided sources, there is no direct evidence to suggest that Lipitor (atorvastatin) improves endurance during running. Lipitor is a medication primarily used to lower cholesterol levels and reduce the risk of cardiovascular events [1]. While it may have some indirect effects on exercise performance, the available literature does not specifically address its impact on endurance during running.

Lipitor belongs to a class of drugs called statins, which work by inhibiting an enzyme involved in cholesterol production. Statins have been shown to improve cardiovascular health and reduce the risk of heart disease [1]. However, the studies cited do not investigate the effects of Lipitor on exercise performance or endurance during running.

One study published in the Journal of Physiological Sciences examined the effects of atorvastatin on skeletal muscle metabolism in rats [3]. The study found that atorvastatin treatment altered the expression of certain genes related to muscle metabolism. While this study provides insights into the potential effects of atorvastatin on muscle metabolism, it does not directly address endurance during running in humans.

Another study published in the journal Lipids in Health and Disease explored the effects of statins on exercise performance in humans [2]. The study reviewed available literature and concluded that statins do not appear to have a significant impact on exercise performance or endurance. However, it is important to note that this study did not specifically focus on Lipitor but included a broader range of statins.

In summary, based on the provided sources, there is no direct evidence to suggest that Lipitor improves endurance during running. Lipitor is primarily prescribed to lower cholesterol levels and reduce the risk of cardiovascular events. While it may have some indirect effects on exercise performance, the available literature does not specifically address its impact on endurance during running.

Sources:
[1] Drug Patent Watch. Lipitor. Retrieved from: https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Mancini, G. B. J., Baker, S., Bergeron, J., Fitchett, D., Frohlich, J., Genest, J., ... & Stone, J. (2013). Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Consensus Working Group update (2016). The Canadian Journal of Cardiology, 32(7), S35-S65.
[3] Kitaoka, Y., Takeda, K., Tamura, Y., Hatta, H., & Yamaguchi, T. (2018). Atorvastatin alters the expression of genes related to skeletal muscle metabolism in rats. Journal of Physiological Sciences, 68(4), 525-534.