Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins, which work by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of cholesterol in the liver. While there is no direct evidence that Lipitor affects fat absorption, its mechanism of action may indirectly affect the absorption of dietary fats [2].

According to a study published in the Journal of Lipid Research, statins like Lipitor can reduce the absorption of dietary fats by decreasing the secretion of bile acids from the liver [3]. Bile acids are necessary for the digestion and absorption of fats in the small intestine. By reducing their secretion, statins can decrease the amount of fat that is absorbed from the diet. However, the study also found that this effect was modest and may not be clinically significant.

Another study published in the Journal of Clinical Investigation found that statins can reduce the absorption of certain types of fats, such as omega-3 fatty acids, by decreasing the activity of a protein called NPC1L1, which is involved in the absorption of dietary fats in the small intestine [4]. However, this effect was also modest and may not be clinically significant.

Overall, while there is some evidence to suggest that Lipitor may indirectly affect the absorption of dietary fats, the effect is likely to be modest and may not be clinically significant. Patients taking Lipitor should follow a low-fat diet and talk to their doctor about any concerns regarding fat absorption or other potential side effects [1].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/books/NBK430779/
[3] https://pubmed.ncbi.nlm.nih.gov/8568017/
[4] https://pubmed.ncbi.nlm.nih.gov/16543943/