Based on the available information, there are physical limits with Lipitor (atorvastatin) use, primarily related to the dosage and potential side effects.
The first source, [1](https://www.drugpatentwatch.com/p/tradename/LIPITOR), does not provide specific information on physical limits regarding Lipitor use. However, it does mention that Lipitor is a medication used to treat high cholesterol and reduce the risk of stroke and heart attack.
The second source, [2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949584/), provides information on the pharmacokinetics and pharmacodynamics of atorvastatin. According to this source, atorvastatin is rapidly absorbed and has a half-life of approximately 14 hours. The source also mentions that the maximum recommended dosage of atorvastatin is 80 mg per day, indicating a physical limit to the dosage that can be safely administered.
The third source, [3](https://pubmed.ncbi.nlm.nih.gov/28807461/), discusses the potential side effects of atorvastatin, including myopathy and rhabdomyolysis. These conditions can occur when atorvastatin is used in high doses or in combination with other medications that affect liver function. This source suggests that there are physical limits to the safe use of atorvastatin due to the potential for these serious side effects.
In summary, based on the available information, there are physical limits with Lipitor (atorvastatin) use, primarily related to the dosage and potential side effects. The maximum recommended dosage of atorvastatin is 80 mg per day, and the medication should be used with caution due to the potential for serious side effects such as myopathy and rhabdomyolysis.
Sources:
* [1](https://www.drugpatentwatch.com/p/tradename/LIPITOR) - DrugPatentWatch
* [2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949584/) - Pharmacokinetics and Pharmacodynamics of Atorvastatin
* [3](https://pubmed.ncbi.nlm.nih.gov/28807461/) - Statin-Associated Myopathy: A Systematic Review and Meta-Analysis